Open AccessSupramolecular Nanofibers Enhance Growth Factor Signaling by Increasing Lipid Raft Mobility
Author(s) -
Christina J. Newcomb,
Shantanu Sur,
Sungsoo S. Lee,
Jack Yu,
Yan Zhou,
Malcolm L. Snead,
Samuel I. Stupp
Publication year - 2016
Publication title -
nano letters
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 4.853
H-Index - 488
eISSN - 1530-6992
pISSN - 1530-6984
DOI - 10.1021/acs.nanolett.6b00054
Subject(s) - lipid raft , wnt signaling pathway , microbiology and biotechnology , nanotechnology , nanofiber , signal transduction , growth factor , nanomedicine , raft , chemistry , biophysics , materials science , nanostructure , biochemistry , biology , receptor , nanoparticle , organic chemistry , copolymer , polymer
The nanostructures of self-assembling biomaterials have been previously designed to tune the release of growth factors in order to optimize biological repair and regeneration. We report here on the discovery that weakly cohesive peptide nanostructures in terms of intermolecular hydrogen bonding, when combined with low concentrations of osteogenic growth factor, enhance both BMP-2 and Wnt mediated signaling in myoblasts and bone marrow stromal cells, respectively. Conversely, analogous nanostructures with enhanced levels of internal hydrogen bonding and cohesion lead to an overall reduction in BMP-2 signaling. We propose that the mechanism for enhanced growth factor signaling by the nanostructures is related to their ability to increase diffusion within membrane lipid rafts. The phenomenon reported here could lead to new nanomedicine strategies to mediate growth factor signaling for translational targets.