Imaging of Cell Morphology Changes via Metamaterial-Assisted Photobleaching Microscopy | Zendy

Yeon Ui Lee | Zendy; Clara Posner | Zendy; Junxiang Zhao | Zendy; Jin Zhang | Zendy; Zhaowei Liu | Zendy

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Imaging of Cell Morphology Changes via Metamaterial-Assisted Photobleaching Microscopy

Author(s) -

Yeon Ui Lee,

Clara Posner,

Junxiang Zhao,

Jin Zhang,

Zhaowei Liu

Publication year - 2021

Publication title -

nano letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 4.853

H-Index - 488

eISSN - 1530-6992

pISSN - 1530-6984

DOI - 10.1021/acs.nanolett.0c04529

Subject(s) - photobleaching , microscopy , resolution (logic) , materials science , live cell imaging , morphology (biology) , metamaterial , nanoscopic scale , optics , nanotechnology , chemistry , optoelectronics , physics , cell , biology , fluorescence , computer science , genetics , biochemistry , artificial intelligence

Determining the axial position of an emitter with nanoscale precision is critical to a fundamental imaging methodology. While there are many advanced optical techniques being applied to high-resolution imaging, high-axial-resolution topography imaging of living cells is particularly challenging. Here, we present an application of metamaterial-assisted photobleaching microscopy (MAPM) with high-axial resolution to characterize morphological properties of living cells. Quantitative imaging of changes in the morphology of live cells is obtained by topographic and statistical analysis. The time-lapse topography image using the metamaterial-induced photostability provides information about growth factor induced changes in the cell morphology with high-axial resolution.

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