Open AccessEnzyme-Guided Selection and Cascaded Emergence of Nanostructured Constitutional Dynamic Networks
Author(s) -
Shan Wang,
Liang Yue,
Itamar Willner
Publication year - 2020
Publication title -
nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.853
H-Index - 488
eISSN - 1530-6992
pISSN - 1530-6984
DOI - 10.1021/acs.nanolett.0c01939
Subject(s) - ecori , selection (genetic algorithm) , hindiii , restriction enzyme , computer science , computational biology , chemistry , biology , genetics , dna , artificial intelligence
Enzymes (endonucleases) are coupled to constitutional dynamic networks to stimulate the selection of a constituent and cascaded emergence of a new network. This is exemplified with the Eco RI-dictated depletion of a network and selection of a constituent that activates the cascaded emergence of a new network. The new network is further depleted by Hin dIII to a selected constituent that can be coupled to the cascaded emergence of a dynamic network. In addition, upon subjecting a [3 × 3] constitutional dynamic network to endonucleases Eco RI and Hin dIII, the programmed hierarchical selection of [2 × 2] constitutional dynamic networks followed by the biocatalytic selection of a constituent for the subsequent emergence of new networks is demonstrated.