Open AccessSelective Binding of Complex Glycans and Glycoproteins in Water by Molecularly Imprinted Nanoparticles
Author(s) -
Milad Zangiabadi,
Yan Zhao
Publication year - 2020
Publication title -
nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 4.853
H-Index - 488
eISSN - 1530-6992
pISSN - 1530-6984
DOI - 10.1021/acs.nanolett.0c01305
Subject(s) - glycan , chemistry , affinities , hydrogen bond , molecular imprinting , glycoprotein , micelle , solvation , molecular recognition , nanoparticle , pulmonary surfactant , receptor , combinatorial chemistry , molecule , biophysics , nanotechnology , biochemistry , organic chemistry , selectivity , materials science , aqueous solution , biology , catalysis
Synthetic receptors to recognize biological glycans are in great need for modern glycoscience and technology, but their design and synthesis have been a daunting challenge due to strong solvation of carbohydrates in water and structural complexity of the guest. Molecular imprinting in surfactant micelles with amide cross-linkers provides a convenient one-pot method to prepare nanoparticle receptors for glycosides, glycans, and glycoproteins, taking advantage of hydrogen-bonding interactions near the surfactant/water interface. Biologically competitive micromolar binding affinities were obtained in water and subtle structural differences of glycans could be distinguished.