Perspective on Proteomics for Virus Detection in Clinical Samples | Zendy

Marica Grossegesse | Zendy; Felix Hartkopf | Zendy; Andreas Nitsche | Zendy; Lars Schaade | Zendy; Joerg Doellinger | Zendy; Thilo Muth | Zendy

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Perspective on Proteomics for Virus Detection in Clinical Samples

Author(s) -

Marica Grossegesse,

Felix Hartkopf,

Andreas Nitsche,

Lars Schaade,

Joerg Doellinger,

Thilo Muth

Publication year - 2020

Publication title -

journal of proteome research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.644

H-Index - 161

eISSN - 1535-3907

pISSN - 1535-3893

DOI - 10.1021/acs.jproteome.0c00674

Subject(s) - proteomics , computational biology , virus , molecular diagnostics , pandemic , covid-19 , virology , biology , bioinformatics , medicine , disease , pathology , infectious disease (medical specialty) , biochemistry , gene

One of the most widely used methods to detect an acute viral infection in clinical specimens is diagnostic real-time polymerase chain reaction. However, because of the COVID-19 pandemic, mass-spectrometry-based proteomics is currently being discussed as a potential diagnostic method for viral infections. Because proteomics is not yet applied in routine virus diagnostics, here we discuss its potential to detect viral infections. Apart from theoretical considerations, the current status and technical limitations are considered. Finally, the challenges that have to be overcome to establish proteomics in routine virus diagnostics are highlighted.

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