Bacillus subtilis Lipid Extract, A Branched-Chain Fatty Acid Model Membrane | Zendy

Jonathan D. Nickels | Zendy; Sneha Chatterjee | Zendy; Barmak Mostofian | Zendy; Christopher B. Stanley | Zendy; Michael Ohl | Zendy; Piotr Zolnierczuk | Zendy; Roland Schulz | Zendy; Dean A. A. Myles | Zendy; Robert F. Standaert | Zendy; James G. Elkins | Zendy; Xiaolin Cheng | Zendy; John Katsaras | Zendy

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Bacillus subtilis Lipid Extract, A Branched-Chain Fatty Acid Model Membrane

Author(s) -

Jonathan D. Nickels,

Sneha Chatterjee,

Barmak Mostofian,

Christopher B. Stanley,

Michael Ohl,

Piotr Zolnierczuk,

Roland Schulz,

Dean A. A. Myles,

Robert F. Standaert,

James G. Elkins,

Xiaolin Cheng,

John Katsaras

Publication year - 2017

Publication title -

the journal of physical chemistry letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.563

H-Index - 203

ISSN - 1948-7185

DOI - 10.1021/acs.jpclett.7b01877

Subject(s) - bacillus subtilis , chemistry , fatty acid , biochemistry , bacteria , biology , genetics

Lipid extracts are an excellent choice of model biomembrane; however at present, there are no commercially available lipid extracts or computational models that mimic microbial membranes containing the branched-chain fatty acids found in many pathogenic and industrially relevant bacteria. We advance the extract of Bacillus subtilis as a standard model for these diverse systems, providing a detailed experimental description and equilibrated atomistic bilayer model included as Supporting Information to this Letter and at ( http://cmb.ornl.gov/members/cheng ). The development and validation of this model represents an advance that enables more realistic simulations and experiments on bacterial membranes and reconstituted bacterial membrane proteins.

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