Open AccessGeneralizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange
Author(s) -
Johannes F. P. Colell,
Angus W. J. Logan,
Zijian Zhou,
Roman V. Shchepin,
Danila A. Barskiy,
Gerardo X. Ortiz,
Qiu Wang,
Steven J. Malcolmson,
Eduard Y. Chekmenev,
Warren S. Warren,
Thomas Theis
Publication year - 2017
Publication title -
journal of physical chemistry. c./journal of physical chemistry. c
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 289
eISSN - 1932-7455
pISSN - 1932-7447
DOI - 10.1021/acs.jpcc.6b12097
Subject(s) - spin isomers of hydrogen , hyperpolarization (physics) , heteronuclear molecule , chemistry , polarization (electrochemistry) , nitrogen , induced polarization , nuclear magnetic resonance , chemical physics , nuclear magnetic resonance spectroscopy , hydrogen , physics , stereochemistry , organic chemistry , quantum mechanics , electrical resistivity and conductivity
Signal Amplification by Reversible Exchange (SABRE) is a fast and convenient NMR hyperpolarization method that uses cheap and readily available para -hydrogen as a hyperpolarization source. SABRE can hyperpolarize protons and heteronuclei. Here we focus on the heteronuclear variant introduced as SABRE-SHEATH (SABRE in SHield Enables Alignment Transfer to Heteronuclei) and nitrogen-15 targets in particular. We show that 15 N-SABRE works more efficiently and on a wider range of substrates than 1 H-SABRE, greatly generalizing the SABRE approach. In addition, we show that nitrogen-15 offers significantly extended T 1 times of up to 12 minutes. Long T 1 times enable higher hyperpolarization levels but also hold the promise of hyperpolarized molecular imaging for several tens of minutes. Detailed characterization and optimization are presented, leading to nitrogen-15 polarization levels in excess of 10% on several compounds.