Inhibition of Fibrillar Assemblies of l-Phenylalanine by Crown Ethers: A Potential Approach toward Phenylketonuria | Zendy

Debasis Banik | Zendy; Rupam Dutta | Zendy; Pavel Banerjee | Zendy; Sangita Kundu | Zendy; Nilmoni Sarkar | Zendy

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Inhibition of Fibrillar Assemblies of l-Phenylalanine by Crown Ethers: A Potential Approach toward Phenylketonuria

Author(s) -

Debasis Banik,

Rupam Dutta,

Pavel Banerjee,

Sangita Kundu,

Nilmoni Sarkar

Publication year - 2016

Publication title -

the journal of physical chemistry b

Language(s) - English

Resource type - Journals

eISSN - 1520-6106

pISSN - 1520-5207

DOI - 10.1021/acs.jpcb.6b05209

Subject(s) - phenylalanine , fibril , crown (dentistry) , kinetics , biophysics , chemistry , fluorescence microscope , transmission electron microscopy , fluorescence , crystallography , materials science , biochemistry , amino acid , nanotechnology , biology , optics , composite material , physics , quantum mechanics

In this article, our aim is to investigate the interaction of l-phenylalanine (l-Phe) fibrils with crown ethers (CEs). For this purpose, two different CEs (15-Crown-5 (15C5) and 18-Crown-6 (18C6)) were used. Interestingly, we have observed that both CEs have the ability to arrest fibril formation. However, 18C6 was found to be a better candidate compared to 15C5. Field emission scanning electron microscopy and fluorescence lifetime imaging microscopy were used to monitor the fibril-arresting kinetics of CEs. The arresting process was further confirmed by fluorescence correlation spectroscopy and nuclear magnetic resonance studies.

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