Open AccessTotal Internal Reflection Transient Absorption Microscopy: An Online Detection Method for Microfluidics
Author(s) -
Brandon A. Colon,
Muhammad Redwan Hassan,
Amirus Saleheen,
Carol S. Baker,
Tessa R. Calhoun
Publication year - 2020
Publication title -
the journal of physical chemistry. a/the journal of physical chemistry. a.
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.756
H-Index - 235
eISSN - 1520-5215
pISSN - 1089-5639
DOI - 10.1021/acs.jpca.9b12046
Subject(s) - microfluidics , chromophore , microreactor , reflection (computer programming) , absorption (acoustics) , transient (computer programming) , chemistry , microscopy , microscope , nanotechnology , total internal reflection , total internal reflection fluorescence microscope , optoelectronics , optics , materials science , computer science , photochemistry , biochemistry , physics , operating system , programming language , catalysis
Microreactors have garnered widespread attention for their tunability and precise control of synthetic parameters to efficiently produce target species. Despite associated advances, a lack of online detection and optimization methods has stalled the progression of microfluidic reactors. Here we employ and characterize a total internal reflection transient absorption microscopy (TIRTAM) instrument to image excited state dynamics on a continuous flow device. The experiments presented demonstrate the capability to discriminate between different chromophores as well as in differentiating the effects of local chemical environments that a chromophore experiences. This work presents the first such online transient absorption measurements and provides a new direction for the advancement and optimization of chemical reactions in microfluidic devices.