Open AccessUnexpected Formation of Hexasubstituted Arenes through a 2-fold Palladium-Mediated Ligand Arylation
Author(s) -
Corin Wagen,
Bryan T. Ingoglia,
Stephen L. Buchwald
Publication year - 2019
Publication title -
journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/acs.joc.9b02091
Subject(s) - palladium , chemistry , stereochemistry , ligand (biochemistry) , molecule , medicinal chemistry , crystallography , receptor , catalysis , organic chemistry , biochemistry
A rearrangement reaction of biarylphosphine-supported Pd(II) complexes was employed to synthesize 1,3,5-triaryl 2,4,6-triisopropylbenzene compounds, a class of molecules that has not previously been reported. The strain of the central hexasubstituted ring was investigated via X-ray crystallography.