Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates | Zendy

Peihe Li | Zendy; Nuannuan Ma | Zendy; Zheng Wang | Zendy; Qipu Dai | Zendy; Changwen Hu | Zendy

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Base-Mediated Intramolecular Decarboxylative Synthesis of Alkylamines from Alkanoyloxycarbamates

Author(s) -

Peihe Li,

Nuannuan Ma,

Zheng Wang,

Qipu Dai,

Changwen Hu

Publication year - 2018

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.8b00970

Subject(s) - chemistry , decarboxylation , intramolecular force , hydroxylamine , alkyl , base (topology) , primary (astronomy) , organic chemistry , combinatorial chemistry , medicinal chemistry , catalysis , mathematical analysis , physics , mathematics , astronomy

A general and effective method for the synthesis of alkylamine via intramolecular decarboxylation of alkanoyloxycarbamates is described. The alkanoyloxycarbamates are readily prepared with alkyl carboxylic acids and hydroxylamine. The reaction shows a broad range of substrates (primary and secondary alkyl) with functional tolerance, and the corresponding products were obtained in good yields under mild conditions.

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