Open AccessMethod for Accessing Nitrogen-Containing, B-Heteroaryl-Substituted 2,1-Borazaronaphthalenes
Author(s) -
Geraint H. M. Davies,
ZhaoZhao Zhou,
Matthieu Jouffroy,
Gary A. Molander
Publication year - 2016
Publication title -
journal of organic chemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/acs.joc.6b02574
Subject(s) - chemistry , surface modification , nitrogen , combinatorial chemistry , archetype , stereochemistry , organic chemistry , art , literature
The azaborine motif provides a mimic of aromatic systems through replacement of a C═C bond with a B-N bond. In particular, 2,1-borazaronaphthalenes, accessible through robust methods of synthesis and subsequent functionalization, afford an ideal platform to use for a variety of applications. However, the scope of substructures for this archetype has been limited by the lack of nitrogen-containing heteroaryls that can be incorporated within them. In this study, modified reaction conditions were developed to provide access to a wider range of substructures.