Open AccessPalladium-Catalyzed Acylations: One-Pot Synthesis of Indenones
Author(s) -
Basuli Suchand,
Gedu Satyanarayana
Publication year - 2016
Publication title -
the journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/acs.joc.6b02453
Subject(s) - chemistry , aldol condensation , acylation , palladium , catalysis , combinatorial chemistry , condensation , natural product , intramolecular force , organic chemistry , physics , thermodynamics
An efficient, one-pot synthesis of substituted indenones was accomplished starting from simple o-iodoketones and aldehydes. [Pd]-catalyzed direct acylation of o-iodoketones with aldehydes was employed as the key step. Subsequent intramolecular aldol condensation afforded the indenones. Notably, a variety of indenones were achieved. Significantly, the natural product neolignan was accomplished in one pot.
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