C–N Coupling of Amides with Alcohols Catalyzed by N-Heterocyclic Carbene–Phosphine Iridium Complexes | Zendy

Sutthichat Kerdphon | Zendy; Xu Quan | Zendy; Vijay Singh Parihar | Zendy; Pher G. Andersson | Zendy

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C–N Coupling of Amides with Alcohols Catalyzed by N-Heterocyclic Carbene–Phosphine Iridium Complexes

Author(s) -

Sutthichat Kerdphon,

Xu Quan,

Vijay Singh Parihar,

Pher G. Andersson

Publication year - 2015

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.5b01324

Subject(s) - chemistry , iridium , carbene , phosphine , catalysis , coupling (piping) , organic chemistry , medicinal chemistry , combinatorial chemistry , mechanical engineering , engineering

N-Heterocyclic carbene-phosphine iridium complexes (NHC-Ir) were developed/found to be a highly reactive catalyst for N-monoalkylation of amides with alcohols via hydrogen transfer. The reaction produced the desired product in high isolated yields using a wide range of substrates with low catalyst loading and short reaction times.

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