Preparation of Tetrasubstituted Olefins Using Mono or Double Aerobic Direct C–H Functionalization Strategies: Importance of Steric Effects | Zendy

Nicolas Gigant | Zendy; François Quintin | Zendy; JanE. Bäckvall | Zendy

Open Access

Preparation of Tetrasubstituted Olefins Using Mono or Double Aerobic Direct C–H Functionalization Strategies: Importance of Steric Effects

Author(s) -

Nicolas Gigant,

François Quintin,

JanE. Bäckvall

Publication year - 2015

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.5b00148

Subject(s) - chemistry , steric effects , surface modification , limiting , combinatorial chemistry , oxygen , organic chemistry , mechanical engineering , engineering

A novel protocol for the synthesis of tetrasubstituted olefins through a biomimetic approach has been explored. Both mono- and diarylations were performed under ambient oxygen pressure, giving a range of highly hindered tetrasubstituted alkenes. For diarylation of disubstituted substrates, it was demonstrated that the second arylation is the rate-limiting step of the overall transformation.

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