Mechanochemical Synthesis of Primary Amides | Zendy

Jorge Gómez-Carpintero | Zendy; J. Domingo Sánchez | Zendy; Juan F. González | Zendy; J. Carlos Menéndez | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Mechanochemical Synthesis of Primary Amides

Author(s) -

Jorge Gómez-Carpintero,

J. Domingo Sánchez,

Juan F. González,

J. Carlos Menéndez

Publication year - 2021

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.1c02350

Subject(s) - stereocenter , primary (astronomy) , dipeptide , chemistry , organic chemistry , mechanochemistry , ethanol , amino acid , catalysis , biochemistry , enantioselective synthesis , physics , astronomy

Ball milling of aromatic, heteroaromatic, vinylic, and aliphatic esters with ethanol and calcium nitride afforded the corresponding primary amides in a transformation that was compatible with a variety of functional groups and maintained the integrity of a stereocenter α to carbonyl. This methodology was applied to α-amino esters and N -BOC dipeptide esters and also to the synthesis of rufinamide, an antiepileptic drug.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research