Open AccessChromium–Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols
Author(s) -
Sumio Nagasawa,
Shogo Fujiki,
Yusuke Sasano,
Yoshiharu Iwabuchi
Publication year - 2021
Publication title -
journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/acs.joc.1c00438
Subject(s) - intramolecular force , nitroxyl , catalysis , chromium , chemistry , phenols , coupling reaction , photochemistry , coupling (piping) , polymer chemistry , organic chemistry , materials science , metallurgy
We describe an aerobic intramolecular dearomative coupling reaction of tethered phenols using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.