Chromium–Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols | Zendy

Shota Nagasawa | Zendy; Shogo Fujiki | Zendy; Yusuke Sasano | Zendy; Yoshiharu Iwabuchi | Zendy

Open Access

Chromium–Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols

Author(s) -

Shota Nagasawa,

Shogo Fujiki,

Yusuke Sasano,

Yoshiharu Iwabuchi

Publication year - 2021

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.1c00438

Subject(s) - intramolecular force , chromium , nitroxyl , catalysis , phenols , coupling (piping) , chemistry , photochemistry , polymer chemistry , organic chemistry , materials science , metallurgy

We describe an aerobic intramolecular dearomative coupling reaction of tethered phenols using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

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