Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes | Zendy

Robin Jeanneret | Zendy; Simon E. Johnson | Zendy; M. Carmen Galán | Zendy

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Conformationally Constrained Glycosyl Donors as Tools to Control Glycosylation Outcomes

Author(s) -

Robin Jeanneret,

Simon E. Johnson,

M. Carmen Galán

Publication year - 2020

Publication title -

the journal of organic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.2

H-Index - 228

eISSN - 1520-6904

pISSN - 0022-3263

DOI - 10.1021/acs.joc.0c02045

Subject(s) - glycosylation , glycosyl , glycosyl donor , stereoselectivity , chemistry , reactivity (psychology) , carbohydrate chemistry , glycosyltransferase , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , biochemistry , enzyme , medicine , alternative medicine , pathology

The stereoselective synthesis of oligosaccharides remains one of the biggest challenges in carbohydrate chemistry. Many factors, including reaction conditions and the type of glycosyl donor and acceptor used, can affect the outcome of glycosylation reactions. In this Perspective, we discuss methods aimed to control the reactivity and stereoselectivity of glycosylation reactions using conformationally constrained glycosyl donors, with a focus on more recently developed chemistry.

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