Open AccessN-Aminopyridinium Ylide-Directed, Copper-Promoted Chalcogenation of Arene C–H Bonds
Author(s) -
Hanh Nho Nguyen,
Olafs Daugulis
Publication year - 2020
Publication title -
journal of organic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.2
H-Index - 228
eISSN - 1520-6904
pISSN - 0022-3263
DOI - 10.1021/acs.joc.0c01757
Subject(s) - chemistry , ylide , copper , alkyl , medicinal chemistry , aryl , solvent , polymer chemistry , stereochemistry , organic chemistry
N -Aminopyridinium ylide-directing group is employed for copper-promoted chalcogenation of sp 2 C-H bonds with aryl and alkyl disulfides as well as diphenyl diselenide. Reactions proceed in hexafluoroisopropanol (HFIP) solvent at elevated temperatures and are promoted by copper(II) acetate.