Open Access(9βH)- and 17-Nor-Pimaranes from Icacina oliviformis
Author(s) -
Meng Sun,
Brian Guo,
Mingming Xu,
Ming Zhao,
Monday M. Onakpa,
ZhenLong Wu,
Joanna E. Burdette,
ChunTao Che
Publication year - 2021
Publication title -
journal of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 139
eISSN - 1520-6025
pISSN - 0163-3864
DOI - 10.1021/acs.jnatprod.9b01131
Subject(s) - stereochemistry , cancer cell lines , cytotoxic t cell , pharmacognosy , terpenoid , chemistry , biology , traditional medicine , biological activity , cancer , cancer cell , biochemistry , in vitro , medicine , genetics
Eleven pimarane-type diterpenoids were isolated from the tubers of Icacina oliviformis , including three new compounds, icacinlactone M ( 9 ), icacinlactone H 2- O -β-d-glucopyranoside ( 10 ), and icacinlactone N 3- O -β-d-glucopyranoside ( 11 ), together with an artifact of acrenol ( 8 ). Among the known structures, icacinlactone A ( 2 ), icacinlactone B ( 3 ), icacinlactone H ( 4 ), 12-hydroxyicacinlactone A ( 5 ), 14α-methoxyhumirianthol ( 6 ), and annonalide ( 7 ) are reported from I. oliviformis for the first time, whereas icacinol ( 1 ) has previously been found in this plant. Icacinol, 14α-methoxyhumirianthol, and annonalide displayed moderate cytotoxic activity in a panel of human cancer cell lines.