Engineering Fluorine into Verticillins (Epipolythiodioxopiperazine Alkaloids) via Precursor-Directed Biosynthesis | Zendy

Chiraz Soumia M. Amrine | Zendy; Jessica L. Long | Zendy; Huzefa A. Raja | Zendy; Steven J. Kurina | Zendy; Joanna E. Burdette | Zendy; Cedric J. Pearce | Zendy; Nicholas H. Oberlies | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Engineering Fluorine into Verticillins (Epipolythiodioxopiperazine Alkaloids) via Precursor-Directed Biosynthesis

Author(s) -

Chiraz Soumia M. Amrine,

Jessica L. Long,

Huzefa A. Raja,

Steven J. Kurina,

Joanna E. Burdette,

Cedric J. Pearce,

Nicholas H. Oberlies

Publication year - 2019

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.9b00711

Subject(s) - biosynthesis , chemistry , mass spectrometry , chemical synthesis , stereochemistry , combinatorial chemistry , cancer cell lines , biochemistry , cancer cell , in vitro , biology , chromatography , enzyme , cancer , genetics

Precursor-directed biosynthesis was used to generate a series of fluorinated verticillins. The biosynthesis of these epipolythiodioxopiperazine alkaloids was monitored in situ via the droplet liquid microjunction surface sampling probe (droplet probe), and a suite of NMR and mass spectrometry data were used for their characterization. All analogues demonstrated nanomolar IC 50 values vs a panel of cancer cell lines. This approach yielded new compounds that would be difficult to generate via synthesis.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research