Open AccessNeoclerodane Diterpenoids from Reehal Fatima, Teucrium yemense
Author(s) -
Mohammad NureAlam,
Muhammad Yousaf,
Sarfaraz Ahmed,
Ebtesam S. AlSheddi,
Ifat Parveen,
David M. Fazakerley,
Ahmed Bari,
Hazem A. Ghabbour,
Michael D. Threadgill,
Kezia C. L. Whatley,
Karl F. Hoffmann,
Adnan J. AlRehaily
Publication year - 2017
Publication title -
journal of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 139
eISSN - 1520-6025
pISSN - 0163-3864
DOI - 10.1021/acs.jnatprod.7b00188
Subject(s) - teucrium , lamiaceae , phytochemical , genus , diterpene , traditional medicine , antimicrobial , anthelmintic , biology , botany , stereochemistry , chemistry , microbiology and biotechnology , medicine , zoology
Teucrium yemense (Defl), locally known as Reehal Fatima, is a medicinal plant commonly grown in Saudi Arabia and Yemen. Phytochemical investigation of the aerial parts of T. yemense yielded six new neoclerodane diterpenoids, namely fatimanol A-E (1, 2, 3, 5, and 6) and fatimanone (4), and the known teulepicephin (7). As both the Teucrium genus and the related Lamiaceae family have previously been widely reported to possess anthelmintic and antimicrobial activities, the structural and biological characterization of the seven diterpenoids was pursued. The structures of the new compounds were elucidated from their 2D NMR and MS profiles and by comparison to related compounds. The structure of fatimanol D (5) was confirmed by X-ray crystallographic analysis. The new structures contribute to the breadth of knowledge of secondary metabolites in this genus.
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