Open Access1,3-Oxazin-6-one Derivatives and Bohemamine-Type Pyrrolizidine Alkaloids from a Marine-Derived Streptomyces spinoverrucosus
Author(s) -
Peng Fu,
Scott La,
John B. MacMillan
Publication year - 2015
Publication title -
journal of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 139
eISSN - 1520-6025
pISSN - 0163-3864
DOI - 10.1021/acs.jnatprod.5b00604
Subject(s) - pyrrolizidine , moiety , streptomyces , stereochemistry , chemistry , quantum chemical , pharmacognosy , streptomycetaceae , actinomycetales , organic chemistry , biology , molecule , biological activity , bacteria , biochemistry , in vitro , genetics
Two new 1,3-oxazin-6-one derivatives (1 and 2) and six new bohemamine-type pyrrolizidine alkaloids (3-8) were isolated from the marine-derived Streptomyces spinoverrucosus strain SNB-048. Their structures including the absolute configurations were fully elucidated on the basis of spectroscopic analysis, ECD spectra, quantum chemical calculations, and chemical methods. Compounds 1 and 2 possess a γ-lactam moiety and a 1,3-oxazin-6-one system.