Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum | Zendy

Russell B. Williams | Zendy; Vanessa L. Norman | Zendy; Mark O’Neil-Johnson | Zendy; Scott Woodbury | Zendy; Gary R. Eldridge | Zendy; Courtney M. Starks | Zendy

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Digging Deep for New Compounds from the Compass Plant, Silphium laciniatum

Author(s) -

Russell B. Williams,

Vanessa L. Norman,

Mark O’Neil-Johnson,

Scott Woodbury,

Gary R. Eldridge,

Courtney M. Starks

Publication year - 2015

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.5b00394

Subject(s) - taproot , digging , perennial plant , biology , compass , botany , terpenoid , geography , cartography , archaeology

The compass plant, Silphium laciniatum, is an iconic perennial plant of the North American tallgrass prairie. The plants of the tallgrass prairie historically have been subjected to a number of biological and environmental stresses. Among the adaptations developed by S. laciniatum is a large deep taproot. An investigation of the secondary metabolites found in the root of a S. laciniatum specimen has led to the identification of 15 new terpenoids (3-8, 10-17, and 22), which were screened for cytotoxic activity in the NCI-H460 human large-cell lung carcinoma cell line.

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