Open AccessDigging Deep for New Compounds from the Compass Plant, Silphium laciniatum
Author(s) -
Russell B. Williams,
Vanessa L. Norman,
Mark O’Neil-Johnson,
Scott Woodbury,
Gary R. Eldridge,
Courtney M. Starks
Publication year - 2015
Publication title -
journal of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 139
eISSN - 1520-6025
pISSN - 0163-3864
DOI - 10.1021/acs.jnatprod.5b00394
Subject(s) - taproot , digging , perennial plant , biology , compass , botany , terpenoid , geography , cartography , archaeology
The compass plant, Silphium laciniatum, is an iconic perennial plant of the North American tallgrass prairie. The plants of the tallgrass prairie historically have been subjected to a number of biological and environmental stresses. Among the adaptations developed by S. laciniatum is a large deep taproot. An investigation of the secondary metabolites found in the root of a S. laciniatum specimen has led to the identification of 15 new terpenoids (3-8, 10-17, and 22), which were screened for cytotoxic activity in the NCI-H460 human large-cell lung carcinoma cell line.