Characterization of l-Digitoxosyl-phenanthroviridin from Streptomyces venezuelae ISP5230 | Zendy

Andrew Robertson | Zendy; Camilo F. MartinezFarina | Zendy; Raymond T. Syvitski | Zendy; David L. Jakeman | Zendy

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Characterization of l-Digitoxosyl-phenanthroviridin from Streptomyces venezuelae ISP5230

Author(s) -

Andrew Robertson,

Camilo F. MartinezFarina,

Raymond T. Syvitski,

David L. Jakeman

Publication year - 2015

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.5b00277

Subject(s) - cytotoxicity , streptomyces , stereochemistry , streptomycetaceae , actinomycetales , cancer cell lines , chemistry , tumor cells , cell culture , biochemistry , biology , bacteria , in vitro , cancer cell , cancer , genetics , cancer research

The jadomycin-derived compound l-digitoxosyl-phenanthroviridin was isolated from fermentations of Streptomyces venezuelae ISP5230 grown in nutrient-deficient media with l-lysine as the sole nitrogen source. Structural elucidation was accomplished using a combination of high-resolution MS, LC-MS/MS, and 1D- and 2D-NMR. The compound was evaluated against the National Cancer Institute (NCI) 60 human tumor cell line screen in both the one-dose and five-dose screens, and cytotoxicity was compared to a small library of jadomycin analogues to probe the structure-activity relationship.

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