Open AccessSecoiridoids from Dogwood (Cornus officinalis) Potentiate Progesterone Signaling
Author(s) -
Jung-Ho Lee,
Julia R. Austin,
Joanna E. Burdette,
Brian T. Murphy
Publication year - 2021
Publication title -
journal of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 139
eISSN - 1520-6025
pISSN - 0163-3864
DOI - 10.1021/acs.jnatprod.1c00516
Subject(s) - progesterone receptor , officinalis , estrogen , medicine , endocrinology , hormone , estrogen receptor , receptor , ovary , bioassay , endometriosis , pharmacology , steroid hormone , biology , chemistry , botany , breast cancer , cancer , genetics
The use of botanical dietary supplements for the alleviation of conditions such as hot flashes, premenstrual syndrome, and fertility is prolific worldwide. Estrogen and progesterone receptors (ER and PR) and their corresponding steroid hormones are critical for the relief of hot flashes and the treatment of patients who develop endometriosis, and these pathways can influence the development of endometrial, ovarian, and breast cancers. However, few studies have investigated or identified the natural product components in herbal supplements that act on the PR. In the current study, a new secoiridoid, demethoxy-cornuside ( 1 ), along with six known secoiridoids ( 2 - 7 ) were isolated from the twigs of dogwood ( Cornus officinalis ) by bioassay-guided isolation with a progesterone response element (PRE)/luciferase (Luc) reporter assay in Ishikawa cells. Four phytoprogestins ( 1 , 2 , 6 , 7 ) potentiated the effect of progesterone in the PRE/Luc assay. This study demonstrates that C. officinalis components might potentiate progesterone signaling in the presence of progesterone, which could modify progesterone receptor action in hormone-responsive tissues such as the uterus and mammary gland.