Open AccessIsolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora
Author(s) -
Kouharu Otsuki,
Wei Li,
Kasumi Miura,
Yujiro Asada,
Li Huang,
Chin Ho Chen,
KuoHsiung Lee,
Kazuo Koike
Publication year - 2020
Publication title -
journal of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.976
H-Index - 139
eISSN - 1520-6025
pISSN - 0163-3864
DOI - 10.1021/acs.jnatprod.0c00540
Subject(s) - stereochemistry , diterpene , terpenoid , thymelaeaceae , human immunodeficiency virus (hiv) , ec50 , euphorbiaceae , traditional medicine , pharmacognosy , chemistry , biology , biological activity , in vitro , botany , biochemistry , medicine , virology
Five new [daphneodorins D-H ( 1 , 5 , and 10 - 12 )] and seven known daphnane diterpenoids ( 2 - 4 and 6 - 9 ) were isolated from Daphne odora . The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters ( 1 - 9 ) showed potent anti-HIV activity with EC 50 values of 1.5-7.7 nM.