Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora | Zendy

Kouharu Otsuki | Zendy; Wei Li | Zendy; Kasumi Miura | Zendy; Yoshihisa Asada | Zendy; Li Huang | Zendy; ChinHo Chen | Zendy; KuoHsiung Lee | Zendy; Kazuo Koike | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora

Author(s) -

Kouharu Otsuki,

Wei Li,

Kasumi Miura,

Yoshihisa Asada,

Li Huang,

ChinHo Chen,

KuoHsiung Lee,

Kazuo Koike

Publication year - 2020

Publication title -

journal of natural products

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.976

H-Index - 139

eISSN - 1520-6025

pISSN - 0163-3864

DOI - 10.1021/acs.jnatprod.0c00540

Subject(s) - diterpene , isolation (microbiology) , thymelaeaceae , stereochemistry , human immunodeficiency virus (hiv) , pharmacognosy , chemistry , traditional medicine , biology , biological activity , in vitro , botany , virology , medicine , biochemistry , bioinformatics

Five new [daphneodorins D-H ( 1 , 5 , and 10 - 12 )] and seven known daphnane diterpenoids ( 2 - 4 and 6 - 9 ) were isolated from Daphne odora . The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 infection of MT4 cells. Nine daphnane diterpenoid orthoesters ( 1 - 9 ) showed potent anti-HIV activity with EC 50 values of 1.5-7.7 nM.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research