Open AccessRecent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance
Author(s) -
Yasmeen Abouelhassan,
Aaron T. Garrison,
Hongfen Yang,
Alejandra ChávezRiveros,
Gena M. Burch,
Robert W. Huigens
Publication year - 2019
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.9b00370
Subject(s) - antibiotics , natural product , antibiotic resistance , multidrug tolerance , biofilm , bacteria , microbiology and biotechnology , drug discovery , drug resistance , chemistry , medicine , biology , bioinformatics , genetics , biochemistry
Bacteria utilize multiple mechanisms that enable them to gain or acquire resistance to antibiotic therapies during the treatment of infections. In addition, bacteria form biofilms which are surface-attached communities of enriched populations containing persister cells encased within a protective extracellular matrix of biomolecules, leading to chronic and recurring antibiotic-tolerant infections. Antibiotic resistance and tolerance are major global problems that require innovative therapeutic strategies to address the challenges associated with pathogenic bacteria. Historically, natural products have played a critical role in bringing new therapies to the clinic to treat life-threatening bacterial infections. This Perspective provides an overview of antibiotic resistance and tolerance and highlights recent advances (chemistry, biology, drug discovery, and development) from various research programs involved in the discovery of new antibacterial agents inspired by a diverse series of natural product antibiotics.