Open AccessDiscovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362
Author(s) -
Martin A. Lowe,
Á. de Pablo Cárdenas,
JeanPierre Valentin,
Zhiwei Zhu,
Jan Abendroth,
José L. Castro,
Reiner Class,
Annie Delaunois,
Renaud Fleurance,
Helga Gerets,
Vitalina Gryshkova,
Lloyd E. King,
Donald D. Lorimer,
Malcolm MacCoss,
Julian H. Rowley,
Marie-Luce Rosseels,
Leandro Royer,
Richard D. Taylor,
Melanie Wong,
Oliver Zaccheo,
V. P. Chavan,
Gokul A. Ghule,
Bapusaheb K. Tapkir,
Jeremy N. Burrows,
Maëlle Duffey,
Matthias Rottmann,
Sergio Wittlin,
Íñigo Angulo-Barturen,
Marı́a Belén Jiménez-Dı́az,
Josefine Striepen,
Kate J. Fairhurst,
Tomas Yeo,
David A. Fidock,
Alan F. Cowman,
Paola Favuzza,
Benigno Crespo-Fernández,
Francisco Javier Gamo,
Daniel E. Goldberg,
Dominique SoldatiFavre,
Benoît Laleu,
Teresa de Haro
Publication year - 2022
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.2c01336
Subject(s) - in vivo , pharmacology , drug discovery , plasmodium falciparum , protease , chemistry , malaria , drug , in vitro , drug development , enzyme , medicine , biology , biochemistry , immunology , microbiology and biotechnology