Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362 | Zendy

Martin A. Lowe | Zendy; Á. de Pablo Cárdenas | Zendy; JeanPierre Valentin | Zendy; Zhaoning Zhu | Zendy; Jan Abendroth | Zendy; José L. Castro | Zendy; Reiner Class | Zendy; Annie Delaunois | Zendy; Renaud Fleurance | Zendy; Helga H.J. Gerets | Zendy; Vitalina Gryshkova | Zendy; Lloyd E. King | Zendy; Donald D. Lorimer | Zendy; Malcolm MacCoss | Zendy; Julian H. Rowley | Zendy; MarieLuce Rosseels | Zendy; Leandro Royer | Zendy; Richard D. Taylor | Zendy; Melanie Wong | Zendy; Oliver Zaccheo | Zendy; V. P. Chavan | Zendy; Gokul A. Ghule | Zendy; Bapusaheb K. Tapkir | Zendy; Jeremy N. Burrows | Zendy; Maëlle Duffey | Zendy; Matthias Rottmann | Zendy; Sergio Wittlin | Zendy; Íñigo AnguloBarturen | Zendy; Marı́a Belén Jiménez-Dı́az | Zendy; Josefine Striepen | Zendy; Kate J. Fairhurst | Zendy; Tomas Yeo | Zendy; David A. Fidock | Zendy; Alan F. Cowman | Zendy; Paola Favuzza | Zendy; Benigno Crespo-Fernández | Zendy; FranciscoJavier Gamo | Zendy; Daniel E. Goldberg | Zendy; Dominique SoldatiFavre | Zendy; Benoı̂t Laleu | Zendy; Teresa de Haro | Zendy

Open Access

Discovery and Characterization of Potent, Efficacious, Orally Available Antimalarial Plasmepsin X Inhibitors and Preclinical Safety Assessment of UCB7362

Author(s) -

Martin A. Lowe,

Á. de Pablo Cárdenas,

JeanPierre Valentin,

Zhaoning Zhu,

Jan Abendroth,

José L. Castro,

Reiner Class,

Annie Delaunois,

Renaud Fleurance,

Helga H.J. Gerets,

Vitalina Gryshkova,

Lloyd E. King,

Donald D. Lorimer,

Malcolm MacCoss,

Julian H. Rowley,

MarieLuce Rosseels,

Leandro Royer,

Richard D. Taylor,

Melanie Wong,

Oliver Zaccheo,

V. P. Chavan,

Gokul A. Ghule,

Bapusaheb K. Tapkir,

Jeremy N. Burrows,

Maëlle Duffey,

Matthias Rottmann,

Sergio Wittlin,

Íñigo AnguloBarturen,

Marı́a Belén Jiménez-Dı́az,

Josefine Striepen,

Kate J. Fairhurst,

Tomas Yeo,

David A. Fidock,

Alan F. Cowman,

Paola Favuzza,

Benigno Crespo-Fernández,

FranciscoJavier Gamo,

Daniel E. Goldberg,

Dominique SoldatiFavre,

Benoı̂t Laleu,

Teresa de Haro

Publication year - 2022

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/acs.jmedchem.2c01336

Subject(s) - in vivo , pharmacology , drug discovery , plasmodium falciparum , protease , chemistry , malaria , drug , in vitro , drug development , enzyme , medicine , biology , biochemistry , immunology , microbiology and biotechnology

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