Open AccessTargeting Aggrecanases for Osteoarthritis Therapy: From Zinc Chelation to Exosite Inhibition
Author(s) -
Doretta Cuffaro,
Lidia Ciccone,
Armando Rossello,
Elisa Nuti,
Salvatore Santamaria
Publication year - 2022
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.2c01177
Subject(s) - aggrecanase , chemistry , adamts , disintegrin , aggrecan , metalloproteinase , biochemistry , matrix metalloproteinase , chelation , pharmacology , thrombospondin , osteoarthritis , biology , medicine , alternative medicine , organic chemistry , pathology , articular cartilage