Open AccessDiastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
Author(s) -
Mark S. Cooper,
Linlin Zhang,
Mohamed Ibrahim,
Kaixuan Zhang,
Xinyuanyuan Sun,
Judith Röske,
Matthias Göhl,
Mark Brönstrup,
Justin K. Cowell,
Lucie Sauerhering,
Stephan Becker,
Laura Vangeel,
Dirk Jochmans,
Johan Neyts,
Katharina Rox,
Graham P. Marsh,
Hannah J. Maple,
Rolf Hilgenfeld
Publication year - 2022
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.2c01131
Subject(s) - diastereomer , chemistry , stereochemistry , protease , protease inhibitor (pharmacology) , polyproteins , enzyme inhibitor , enzyme , ic50 , combinatorial chemistry , in vitro , biochemistry , virology , virus , viral load , biology , antiretroviral therapy
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