Open AccessIdentification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro
Author(s) -
Kareem Galal,
Anna Truong,
Frank E. Kwarcinski,
Chandi de Silva,
Krisha Avalani,
Tammy M. Havener,
Michael E. Chirgwin,
Eric M. Merten,
Han Wee Ong,
Caleb Willis,
Ahmad Abdelwaly,
Mohamed A. Helal,
Emily R. Derbyshire,
Reena Zutshi,
David H. Drewry
Publication year - 2022
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.2c00996
Subject(s) - chemistry , ic50 , in vitro , kinase , drug discovery , pharmacology , ec50 , biochemistry , biology