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Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo
Author(s) -
Michał Abram,
Marcin Jakubiec,
Katelyn L. Reeb,
Mary Hongying Cheng,
Robin Gedschold,
Anna Rapacz,
Szczepan Mogilski,
Katarzyna Socała,
Dorota Nieoczym,
Małgorzata Szafarz,
Gniewomir Latacz,
Bartłomiej Szulczyk,
Justyna KalinowskaTłuścik,
Kinga Gaweł,
Camila V. Esguerra,
Elżbieta Wyska,
Christian Müller,
İvet Bahar,
Andréia Cristina Karklin Fontana,
Piotr Właź,
Rafał M. Kamiński,
Krzysztof Kamiński
Publication year - 2022
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.2c00534
Subject(s) - chemistry , allosteric modulator , pharmacology , in vivo , allosteric regulation , pentylenetetrazol , adme , in vitro , pharmacokinetics , drug , epilepsy , biochemistry , receptor , anticonvulsant , biology , neuroscience , microbiology and biotechnology