Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo | Zendy

Michał Abram | Zendy; Marcin Jakubiec | Zendy; Katelyn Reeb | Zendy; Mary Hongying Cheng | Zendy; Robin Gedschold | Zendy; Anna Rapacz | Zendy; Szczepan Mogilski | Zendy; Katarzyna Socała | Zendy; Dorota Nieoczym | Zendy; Małgorzata Szafarz | Zendy; Gniewomir Latacz | Zendy; Bartłomiej Szulczyk | Zendy; Justyna KalinowskaTłuścik | Zendy; Kinga Gaweł | Zendy; Camila V. Esguerra | Zendy; Elżbieta Wyska | Zendy; Christa E. Müller | Zendy; İvet Bahar | Zendy; Andréia C. K. Fontana | Zendy; Piotr Właź | Zendy; Rafał M. Kamiński | Zendy; Krzysztof Kamiński | Zendy

Open Access

Discovery of (R)-N-Benzyl-2-(2,5-dioxopyrrolidin-1-yl)propanamide [(R)-AS-1], a Novel Orally Bioavailable EAAT2 Modulator with Drug-like Properties and Potent Antiseizure Activity In Vivo

Author(s) -

Michał Abram,

Marcin Jakubiec,

Katelyn Reeb,

Mary Hongying Cheng,

Robin Gedschold,

Anna Rapacz,

Szczepan Mogilski,

Katarzyna Socała,

Dorota Nieoczym,

Małgorzata Szafarz,

Gniewomir Latacz,

Bartłomiej Szulczyk,

Justyna KalinowskaTłuścik,

Kinga Gaweł,

Camila V. Esguerra,

Elżbieta Wyska,

Christa E. Müller,

İvet Bahar,

Andréia C. K. Fontana,

Piotr Właź,

Rafał M. Kamiński,

Krzysztof Kamiński

Publication year - 2022

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/acs.jmedchem.2c00534

Subject(s) - chemistry , pharmacology , pentylenetetrazol , in vivo , allosteric modulator , allosteric regulation , adme , pharmacokinetics , in vitro , drug , epilepsy , biochemistry , anticonvulsant , receptor , biology , neuroscience , microbiology and biotechnology

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