Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity | Zendy

Zenichi Ikeda | Zendy; Keiko Kakegawa | Zendy; Fumiaki Kikuchi | Zendy; Sachiko Itono | Zendy; Hideyuki Oki | Zendy; Hiroaki Yashiro | Zendy; Hideyuki Hiyoshi | Zendy; Kazue Tsuchimori | Zendy; Kenichi Hamagami | Zendy; Masanori Watanabe | Zendy; Masako Sasaki | Zendy; Youko Ishihara | Zendy; Kimio Tohyama | Zendy; Tomoyuki Kitazaki | Zendy; Tsuyoshi Maekawa | Zendy; Minoru Sasaki | Zendy

Open Access

Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity

Author(s) -

Zenichi Ikeda,

Keiko Kakegawa,

Fumiaki Kikuchi,

Sachiko Itono,

Hideyuki Oki,

Hiroaki Yashiro,

Hideyuki Hiyoshi,

Kazue Tsuchimori,

Kenichi Hamagami,

Masanori Watanabe,

Masako Sasaki,

Youko Ishihara,

Kimio Tohyama,

Tomoyuki Kitazaki,

Tsuyoshi Maekawa,

Minoru Sasaki

Publication year - 2022

Publication title -

journal of medicinal chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.01

H-Index - 261

eISSN - 1520-4804

pISSN - 0022-2623

DOI - 10.1021/acs.jmedchem.2c00463

Subject(s) - enteropeptidase , chemistry , in vivo , systemic administration , pharmacology , serine protease , protease , moiety , serine , biochemistry , enzyme , stereochemistry , medicine , biology , recombinant dna , fusion protein , gene , microbiology and biotechnology

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