Open AccessTurning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction–Reconstruction and Fragment-Growing Approach
Author(s) -
Giulia Iannelli,
Ciro Milite,
N. Marechal,
Vincent Cura,
L. Bonnefond,
N. Troffer-Charlier,
Alessandra Feoli,
Donatella Rescigno,
Yalong Wang,
Alessandra Cipriano,
Monica Viviano,
Mark T. Bedford,
J. Cavarelli,
Sabrina Castellano,
Gianluca Sbardella
Publication year - 2022
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.2c00252
Subject(s) - methyltransferase , protein arginine methyltransferase 5 , chemistry , methylation , biochemistry , arginine , enzyme , amino acid , gene
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom