Open AccessDiscovery, X-ray Crystallography, and Anti-inflammatory Activity of Bromodomain-containing Protein 4 (BRD4) BD1 Inhibitors Targeting a Distinct New Binding Site
Author(s) -
Zhiqing Liu,
Yi Li,
Haiying Chen,
HsienTsung Lai,
Pingyuan Wang,
SzuYuan Wu,
Eric A. Wold,
Paul G. Leonard,
Sarah Joseph,
Haitao Hu,
ChengMing Chiang,
Allan R. Brasier,
Bing Tian,
Jia Zhou
Publication year - 2022
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.1c01851
Subject(s) - chemistry , bromodomain , brd4 , drug discovery , x ray crystallography , binding site , plasma protein binding , biochemistry , computational biology , histone , dna , biology , diffraction , physics , optics
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