Into Deep Water: Optimizing BCL6 Inhibitors by Growing into a Solvated Pocket
Author(s) -
Matthew G. Lloyd,
Rosemary Huckvale,
Kwai-Ming J. Cheung,
Matthew J. Rodrigues,
Gavin W. Collie,
Olivier A. Pierrat,
Mahad Gatti Iou,
Michael Carter,
Owen A. Davis,
Craig McAndrew,
Emma A. Gunnell,
YannVaï Le Bihan,
Rachel Talbot,
Alan T. Henley,
Louise D. Johnson,
Angela Hayes,
Michael D. Bright,
Florence I. Raynaud,
Mirco Meniconi,
Rosemary Burke,
Rob L. M. van Montfort,
Olivia W. Rossanese,
Benjamin R. Bellenie,
Swen Hoelder
Publication year - 2021
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.1c00946
Subject(s) - chemistry , bcl6 , hydrogen bond , molecule , small molecule , solvent , lead compound , combinatorial chemistry , bound water , stereochemistry , computational chemistry , biochemistry , organic chemistry , in vitro , antibody , immunology , biology , germinal center , b cell
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