Open AccessBuilding a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70
Author(s) -
Yongtao Li,
Wenwei Lin,
William C. Wright,
Sergio C. Chai,
Jing Wu,
Taosheng Chen
Publication year - 2021
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.0c02201
Subject(s) - pregnane x receptor , pharmacophore , chemistry , inverse agonist , partial agonist , pharmacology , agonistic behaviour , drug discovery , antagonist , docking (animal) , receptor , stereochemistry , nuclear receptor , biochemistry , biology , transcription factor , medicine , nursing , psychiatry , gene , aggression , psychology
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