Open AccessDiscovery of Orally Bioavailable Chromone Derivatives as Potent and Selective BRD4 Inhibitors: Scaffold Hopping, Optimization, and Pharmacological Evaluation
Author(s) -
Zhiqing Liu,
Haiying Chen,
Pingyuan Wang,
Yi Li,
Eric A. Wold,
Paul G. Leonard,
Sarah Joseph,
Allan R. Brasier,
Bing Tian,
Jia Zhou
Publication year - 2020
Publication title -
journal of medicinal chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.01
H-Index - 261
eISSN - 1520-4804
pISSN - 0022-2623
DOI - 10.1021/acs.jmedchem.0c00035
Subject(s) - chemistry , brd4 , bromodomain , chromone , in vivo , pharmacology , drug discovery , lead compound , structure–activity relationship , in vitro , biochemistry , stereochemistry , dna , histone , medicine , microbiology and biotechnology , biology
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