Open AccessSelf-Assembly of Porphyrin-Containing Metalla-Assemblies and Cancer Photodynamic Therapy
Author(s) -
Xin Jiang,
Zhixuan Zhou,
Yang Huang,
Chuan Shan,
Hao Yu,
Łukasz Wojtas,
Mingming Zhang,
Zhengwei Mao,
Ming Wang,
Peter J. Stang
Publication year - 2020
Publication title -
inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 233
eISSN - 1520-510X
pISSN - 0020-1669
DOI - 10.1021/acs.inorgchem.9b02775
Subject(s) - porphyrin , chemistry , photodynamic therapy , supramolecular chemistry , small molecule , self assembly , in vivo , combinatorial chemistry , molecule , nanotechnology , photochemistry , organic chemistry , biochemistry , materials science , microbiology and biotechnology , biology
In this report, we describe the synthesis of two porphyrin-containing Pt(II) supramolecular assemblies via coordination-driven self-assembly. X-ray crystallographic analysis on one assembly reveals that the metalla-assembly formation imposes large interchromophore distances, leading to a higher 1 O 2 generation efficiency, relative to the corresponding small molecular precursors. The metalla-assemblies were examined as photosensitizers for photodynamic therapy as the potential reduction of the unfavorable self-aggregation phenomenon. In vivo and in vitro investigations demonstrate that the metalla-assemblies exhibit enhanced anticancer activity with minimal dose requirement and side effects comparable to the small molecule precursors. Thus, our work demonstrates that self-assembly provides a promising methodology for enhancing the therapeutic effectiveness of anticancer agents.