Open AccessComprehensive Vibrational Spectroscopic Investigation of trans,trans,trans-[Pt(N3)2(OH)2(py)2], a Pt(IV) Diazido Anticancer Prodrug Candidate
Author(s) -
Robbin R. Vernooij,
Tanmaya Joshi,
Evyenia Shaili,
Manja Kubeil,
Dominique Appadoo,
Ekaterina I. Izgorodina,
Bimbil Graham,
Peter J. Sadler,
Bayden Robert Wood,
Leone Spiccia
Publication year - 2016
Publication title -
inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 233
eISSN - 1520-510X
pISSN - 0020-1669
DOI - 10.1021/acs.inorgchem.6b00476
Subject(s) - chemistry , ligand (biochemistry) , pyridine , raman spectroscopy , density functional theory , infrared , cis–trans isomerism , thiazole , rotational–vibrational coupling , stereochemistry , molecule , crystallography , computational chemistry , medicinal chemistry , organic chemistry , biochemistry , physics , receptor , optics
We report a detailed study of a promising photoactivatable metal-based anticancer prodrug candidate, trans,trans,trans-[Pt(N3)2(OH)2(py)2] (C1; py = pyridine), using vibrational spectroscopic techniques. Attenuated total reflection Fourier transform infrared (ATR-FTIR), Raman, and synchrotron radiation far-IR (SR-FIR) spectroscopies were applied to obtain highly resolved ligand and Pt-ligand vibrations for C1 and its precursors (trans-[Pt(N3)2(py)2] (C2) and trans-[PtCl2(py)2] (C3)). Distinct IR- and Raman-active vibrational modes were assigned with the aid of density functional theory calculations, and trends in the frequency shifts as a function of changing Pt coordination environment were determined and detailed for the first time. The data provide the ligand and Pt-ligand (azide, hydroxide, pyridine) vibrational signatures for C1 in the mid- and far-IR region, which will provide a basis for the better understanding of the interaction of C1 with biomolecules.