Open AccessSynthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect
Author(s) -
Marta A. Fik-Jaskółka,
Izabela Pospieszna-Markiewicz,
Giovanni N. Roviello,
Maciej Kubicki,
Wanda RadeckaParyzek,
Violetta Patroniak
Publication year - 2021
Publication title -
inorganic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.348
H-Index - 233
eISSN - 1520-510X
pISSN - 0020-1669
DOI - 10.1021/acs.inorgchem.0c03260
Subject(s) - chemistry , lanthanum , antiparallel (mathematics) , dna , salt (chemistry) , stereochemistry , crystallography , inorganic chemistry , combinatorial chemistry , organic chemistry , biochemistry , physics , quantum mechanics , magnetic field
Herein we present a mononuclear lanthanum(III) complex obtained in a template cyclocondensation reaction of lanthanum(III) nitrate salt, 1,2-propanediamine, and 2,6-diacetylpyridine ( LaPA complex). A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target Tel26. We found that, different from parallel G4, antiparallel G4, and duplex DNA, only a hybrid-type G4 structure of Tel26 in a K + solution was significantly stabilized by ≥7 °C, which emerged in our UV melting studies. Moreover, LaPA induced structural changes in the Tel26 structure in a K + -deprived solution, suggesting that it may also lead to conformational changes in "non-G4" telomeric DNA.