4-Hydroxynonenal and 4-Oxononenal Differentially Bind to the Redox Sensor MitoNEET | Zendy

Dayna Ann Maria Arnett | Zendy; Alexandria Quillin | Zendy; Werner J. Geldenhuys | Zendy; Michael A. Menze | Zendy; Mary E. Konkle | Zendy

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4-Hydroxynonenal and 4-Oxononenal Differentially Bind to the Redox Sensor MitoNEET

Author(s) -

Dayna Ann Maria Arnett,

Alexandria Quillin,

Werner J. Geldenhuys,

Michael A. Menze,

Mary E. Konkle

Publication year - 2019

Publication title -

chemical research in toxicology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.031

H-Index - 156

eISSN - 1520-5010

pISSN - 0893-228X

DOI - 10.1021/acs.chemrestox.9b00166

Subject(s) - 4 hydroxynonenal , redox , chemistry , biophysics , nanotechnology , biochemistry , oxidative stress , lipid peroxidation , materials science , biology , organic chemistry

MitoNEET is a CDGSH iron-sulfur protein that has been a target for drug development for diseases such as type-2 diabetes, cancer, and Parkinson's disease. Functions proposed for mitoNEET are as a redox sensor and regulator of free iron in the mitochondria. We have investigated the reactivity of mitoNEET toward the reactive electrophiles 4-hydroxynonenal (HNE) and 4-oxononenal (ONE) that are produced from the oxidation of polyunsaturated fatty acid during oxidative stress. Proteomic, electrophoretic, and spectroscopic analysis has shown that HNE and ONE react in a sequence selective manner that was unexpected considering the structure similarity of these two reactive electrophiles.

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