Open AccessTriterpenoids as Reactive Oxygen Species Modulators of Cell Fate
Author(s) -
Taotao Ling,
Lucinda Boyd,
Fátima Rivas
Publication year - 2022
Publication title -
chemical research in toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 156
eISSN - 1520-5010
pISSN - 0893-228X
DOI - 10.1021/acs.chemrestox.1c00428
Subject(s) - reactive oxygen species , autophagy , programmed cell death , microbiology and biotechnology , triterpenoid , cell , apoptosis , cell fate determination , function (biology) , biology , signal transduction , chemistry , biochemistry , transcription factor , gene , stereochemistry
The triterpenoid natural products have played an important role in understanding mechanistic models of human diseases. These natural products are diverse, but many have been characterized as reactive oxygen species (ROS) modulators. ROS can regulate cell survival and function, which ultimately affects biological processes leading to disease. The triterpenoids offer an untapped source of creativity to generate tool compounds with high selectivity to regulate ROS. This brief Review highlights the diverse complexity by which these secondary metabolites induce many cell death modalities (apoptosis, autophagy, ferroptosis, etc.) that can affect various complex cell signaling pathways through ROS and ultimately lead to evading or accelerating cell death.