Open AccessDisposition of PCB 11 in Mice Following Acute Oral Exposure
Author(s) -
Chun Yun Zhang,
Carolyn Klocke,
Pamela J. Lein,
HansJoachim Lehmler
Publication year - 2021
Publication title -
chemical research in toxicology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.031
H-Index - 156
eISSN - 1520-5010
pISSN - 0893-228X
DOI - 10.1021/acs.chemrestox.1c00067
Subject(s) - adipose tissue , polychlorinated biphenyl , glucuronide , chemistry , toxicity , toxicokinetics , disposition , pharmacology , environmental chemistry , xenobiotic , physiology , toxicology , metabolite , biochemistry , biology , enzyme , organic chemistry , psychology , social psychology
PCB 11 (3,3'-dichloro-biphenyl) is an emerging environmental contaminant that represents a public health concern. Here, we investigated the distribution of PCB 11 and its metabolites in mice exposed orally to PCB 11. PCB 11 tissue levels followed the rank order adipose > lung ∼ muscle > liver > brain > blood 4 h after PCB 11 exposure, which varied from the rank order predicted with a composition-based model. We detected hydroxylated and sulfate metabolites in the liver and sulfate and glucuronide metabolites in serum. These findings lay the groundwork for future toxicity studies with PCB 11.