Open AccessInactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?
Author(s) -
Davide Mileto,
Alessandro Mancon,
Federica Staurenghi,
Alberto Rizzo,
Stefano Econdi,
Maria Rita Gismondo,
Matteo Guidotti
Publication year - 2021
Publication title -
journal of chemical health and safety/journal of chemical health and safety
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.249
H-Index - 21
eISSN - 1878-0504
pISSN - 1871-5532
DOI - 10.1021/acs.chas.0c00095
Subject(s) - disinfectant , hydrogen peroxide , chemistry , aqueous solution , human decontamination , citric acid , coronavirus , sodium citrate , sodium , nuclear chemistry , covid-19 , food science , organic chemistry , medicine , disease , pathology , infectious disease (medical specialty) , physics , nuclear physics
A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log 10 diminution in 15 min. Conversely, H 2 O 2 solutions with no additives displayed a scarce virucidal activity (1.1 log 10 diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H 2 O 2 -based disinfectant active against the novel coronavirus.