Open AccessSelective Crystallization of d -Mannitol Polymorphs Using Surfactant Self-Assembly
Author(s) -
Frederico Marques Penha,
A. V. Gopalan,
Jochem Christoffel Meijlink,
Fatma Ibis,
Hüseyin Burak Eral
Publication year - 2021
Publication title -
crystal growth and design
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.966
H-Index - 155
eISSN - 1528-7505
pISSN - 1528-7483
DOI - 10.1021/acs.cgd.1c00243
Subject(s) - crystallization , pulmonary surfactant , micelle , sodium dodecyl sulfate , mesoscopic physics , d mannitol , self assembly , chemistry , mannitol , chemical engineering , polymorphism (computer science) , crystallography , nanotechnology , materials science , chromatography , organic chemistry , aqueous solution , biochemistry , gene , physics , quantum mechanics , genotype , engineering
Selective crystallization of polymorphs is highly sought after in industrial practice. Yet, state-of-the-art techniques either use laboriously engineered solid surfaces or strenuously prepared heteronucleants. We propose an approach where surfactants in solution self-assemble effortlessly into mesoscopic structures dictating the polymorphic outcome of the target solute. Sodium dodecyl sulfate (SDS) surfactant is used as a tailored additive to crystallize different polymorphic forms of a model active pharmaceutical ingredient, d-mannitol. Different mesoscopic phases of SDS template particular polymorphs: packed monolayers, micelles, and crystals favored the β, α, and δ forms of d-mannitol, respectively. A synergistic effect of topological templating and molecular interactions is proposed as the rationale behind the observed selective crystallization of polymorphs. This crystal engineering technique suggests that surfactant self-assemblies can be used as tailored templates for polymorphic control.