Farnesylated Glycol Chitosan as a Platform for Drug Delivery: Synthesis, Characterization, and Investigation of Mucus–Particle Interactions | Zendy

DuyKhiet Ho | Zendy; Sarah Frisch | Zendy; Alexander Biehl | Zendy; Emmanuel Terriac | Zendy; Chiara Rossi | Zendy; Konrad Schwarzkopf | Zendy; Franziska Lautenschläger | Zendy; Brigitta Loretz | Zendy; Xabier Murgia | Zendy; ClausMichael Lehr | Zendy

Open Access

Farnesylated Glycol Chitosan as a Platform for Drug Delivery: Synthesis, Characterization, and Investigation of Mucus–Particle Interactions

Author(s) -

DuyKhiet Ho,

Sarah Frisch,

Alexander Biehl,

Emmanuel Terriac,

Chiara Rossi,

Konrad Schwarzkopf,

Franziska Lautenschläger,

Brigitta Loretz,

Xabier Murgia,

ClausMichael Lehr

Publication year - 2018

Publication title -

biomacromolecules

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.689

H-Index - 220

eISSN - 1526-4602

pISSN - 1525-7797

DOI - 10.1021/acs.biomac.8b00795

Subject(s) - amphiphile , drug delivery , chitosan , polymer , drug carrier , nanoparticle , chemistry , aqueous solution , controlled release , kinetics , particle size , chemical engineering , nanotechnology , combinatorial chemistry , biophysics , materials science , organic chemistry , copolymer , engineering , physics , quantum mechanics , biology

Amphiphilic polymer-based drug delivery systems hold potential in enhancing pharmacokinetics and therapeutic efficacy due to their ability to simultaneously codeliver different drugs in a controlled manner. We propose here a facile method for synthesizing a new amphiphilic polymer, farnesylated glycol chitosan (FGC), which self-assembles into nanoparticles upon being dispersed in aqueous media. The characteristics of FGC nanoparticles, in particular the size, could be tuned in a range from 200 to 500 nm by modulating the degree of farnesylation and the pH and polymer concentration during particle preparation. Carrier capacity, release kinetics, and surface modification of the established system were investigated using different model compounds. The colloids were biocompatible and stable at biologically relevant pH values. The interactions between the carriers and human mucus were examined by multiple particle tracking, which revealed that ∼80% of the particles remain immobilized within the mucus matrix. These results postulate FGC as a versatile drug delivery platform.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research