Nanoclay–Polyamine Composite Hydrogel for Topical Delivery of Nitric Oxide Gas via Innate Gelation Characteristics of Laponite | Zendy

Kyungtae Park | Zendy; Jonathan I. Dawson | Zendy; Richard O. C. Oreffo | Zendy; YangHee Kim | Zendy; Jinkee Hong | Zendy

Open Access

Nanoclay–Polyamine Composite Hydrogel for Topical Delivery of Nitric Oxide Gas via Innate Gelation Characteristics of Laponite

Author(s) -

Kyungtae Park,

Jonathan I. Dawson,

Richard O. C. Oreffo,

YangHee Kim,

Jinkee Hong

Publication year - 2020

Publication title -

biomacromolecules

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.689

H-Index - 220

eISSN - 1526-4602

pISSN - 1525-7797

DOI - 10.1021/acs.biomac.0c00086

Subject(s) - nitric oxide , molecule , macromolecule , chemistry , fourier transform infrared spectroscopy , viability assay , oxide , composite number , polyamine , polymer chemistry , chemical engineering , materials science , in vitro , organic chemistry , composite material , biochemistry , engineering

Because nitric oxide (NO) gas is an endogenously produced signaling molecule related to numerous physiological functions, manystudies have been conducted to develop NO delivery systems for potential biomedical applications. However, NO is a reactive radical gas molecule that has a very short life-time and readily transforms into nitrogen oxide species via reaction with oxygen species. Therefore, it is necessary to develop an NO delivery carrier that allows local release of the NO gas at the site of application. In this study, Laponite (LP) nanoclay was used to fabricate an NO delivery carrier through the formation of Laponite-polyamine (LP-PA n ) composites. The Laponite clay and pentaethylenehexamine (PEHA) formed a macromolecular structure by electrostatic interaction and the nitric oxide donor, N -diazeniumdiolate (NONOates), was synthesized into the LP-PA n composite. We investigated the conformation of the LP-PA n composite structure and the NO donor formation by ζ potential, X-ray diffraction, and UV-vis and Fourier transform infrared (FT-IR) spectroscopies and also by analyzing the NO release profile. Additionally, we confirmed the applicability in biomedical applications via a cell viability and in vitro endothelial cell tube formation assay.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research