P-Bodies: Composition, Properties, and Functions | Zendy

Yang Luo | Zendy; Zhenkun Na | Zendy; Sarah A. Slavoff | Zendy

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P-Bodies: Composition, Properties, and Functions

Author(s) -

Yang Luo,

Zhenkun Na,

Sarah A. Slavoff

Publication year - 2018

Publication title -

biochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.43

H-Index - 253

eISSN - 1520-4995

pISSN - 0006-2960

DOI - 10.1021/acs.biochem.7b01162

Subject(s) - p bodies , ribonucleoprotein , messenger rna , microbiology and biotechnology , cytoplasm , function (biology) , context (archaeology) , composition (language) , chemistry , rna , biophysics , biology , translation (biology) , biochemistry , gene , paleontology , linguistics , philosophy

Processing bodies (P-bodies) are cytoplasmic ribonucleoprotein (RNP) granules primarily composed of translationally repressed mRNAs and proteins related to mRNA decay, suggesting roles in post-transcriptional regulation. P-bodies are conserved in eukaryotic cells and exhibit properties of liquid droplets. However, the function of P-bodies in translational repression and/or mRNA decay remains contentious. Here we review recent advances in our understanding of the molecular composition of P-bodies, the interactions and processes that regulate P-body liquid-liquid phase separation (LLPS), and the cellular localization of mRNA decay machinery, in the context of how these discoveries refine models of P-body function.

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